Papers of The 4th Japan Scar Workshop
6. New strategy for vocal fold scar using adipose-derived stem cell
Department of Otolaryngology Head and Neck Surgery, Kumamoto University
Graduate School of Medicine, Kumamoto, Japan
Regenerative therapy using stem cells for the treatment of vocal fold
wound healing and fibrosis is a very active area of research in
Otolaryngology. Although modern phonosurgical methods can deal with many
types of vocal fold pathology, vocal fold scar remains a clinical
challenge. Trauma (e.g. vocal abuse, phonosurgery) and inflammation
(e.g. laryngitis) are the two main causes of vocal fold scarring.
Several recent reviews provide details on the problems of vocal fold
scarring and the array of possible solutions under investigation. The
search for solutions includes autologous tissues, biomaterial implants,
growth factors, anti-fibrotic agents and stem cells. This review also
focuses on our own work on interactions between stem cells and vocal
fold fibroblasts using an in vitro model.