Papers of The 3rd Japan Scar Workshop
16. Histological Analysis of Mature Scars, Hypertrophic Scars,
Miki Izumi1, Akira Sugamata2, Satoshi Akaishi3,
1:Department of Pathology, Tokyo Medical University
2:Plastic and Reconstructive Surgery of Tokyo Medical University
Hachioji Medical Center
3:Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon
Medical School Hospital
With regard to the differential diagnosis between keloids and
hypertrophic scars (HSs), while many traditional textbooks of pathology
treat keloids and HSs as completely different types of scars, we have
encountered cases in our clinic where the scar bore features of both
keloids and HSs. Thus, we reattempted to study the histological features
Four typical keloids that were resected by surgery were used for this
study. Specimens were stained with HE and analyzed. Typical pathological
features of mature scars, HSs and keloids were observed in every
specimen. Reticular dermis changed to scars, and contained significantly
higher numbers of macrophages, lymphocytes, and mast cells and higher
proportions of the subpopulations compared to normal skin.
The above findings suggest that histological features of mature scars,
HSs and keloids can be observed in keloids at any time, and that these
features are gradable and thus many intermediate stages may exist.
Careful observation may show that these features differ in degree
between keloids and HSs.