4. A novel therapeutic approaches for wound repair by control release
of basic fibroblast growth factor-impregnated gelatin microspheres
Hiroshi Mizuno, MD
Department of Plastic and Reconstructive Surgery
Division of Regenerative Medicine
Nippon Medical School
Management of severely chronic wound due to peripheral arterial disease
is a challenging procedure since the incidence of such diseases has
increased over time. Recent advancement in the field of regenerative
medicine and tissue engineering suggest that it may eventually be
possible to repair such a wound.
Previous literatures have suggested that basic fibroblast growth
factors-impregnated gelatin microspheres have shown to enhance
angiogenesis in the ischemic hind limb and wound healing in chronic skin
ulcers in vivo. Based on these facts, we have performed clinical trials
for both therapeutic angiogenesis for critical limb ischemia and
treating chronic ulcers. So far, therapeutic successes could be achieved
in 10 cases of angiogenesis and 3 chronic ulcers.
This paper mainly highlights the role of basic fibroblast growth factor
for wound healing, the mechanism of drug delivery system by gelatin
microsphere and our clinical results of such a disease.
