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10. Analysis of nerve subpopulations in hypertrophic scars and
keloids
Noriko Hattori1, Kazuo Kishi1, Hiroko Sato2,
Junji Takano3, Tastuo Nakajima1
1:Departments of Plastic Surgery, School of Medicine, Keio University,
Tokyo, Japan
2:Department of Plastic Surgery, Tokyo Medical Center, National Hospital
Organization, Tokyo, Japan
3:Department of Plastic Surgery, Social Insurance Saitama Hospital,
Saitama, Japan
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BACKGROUND: The aim of our study was to investigate the characteristic
nerve subpopulations in redness sites around keloids to provide a basis
for new clinical treatments of keloids. METHODS: We quantified the
number of nerves among four groups: keloids (center sites and redness
sites), hypertrophic scars, and normal skin. All tissues were fixed with
formalin and embedded in paraffin. Sections were stained with anti-neurofilament
(NF), anti-S-100, and anti-CD31 antibodies. The numbers of nerves and
blood vessels were counted and compared between the four groups.
RESULTS: In contrast to normal skin, significantly higher numbers of
nerves were observed in redness sites and center sites of keloids. There
was no significant difference between redness sites and center sites of
keloids. CONCLUSIONS: The increased numbers of nerves in redness sites
of keloids was similar to center sites of keloids. Neural hypertrophy
might result from the disrupted interplay between wound healing
mechanisms and prevent keloid invasion by controlling innervation of
redness sites around keloids. |
