 |
 |
Papers of The 2nd Japan Scar Workshop |
|
9. The expression of MMPs and TIMPs in keloids
Risa Imaizumi1, Naomi Inomata1, Emi Okada1,
Yu Maruyama1, Yoshikiyo Akasaka2, Toshiharu
Ishii2
1:Department of Plastic and Reconstructive Surgery, Toho University
Omori Medical Center, Tokyo, Japan
2:Department of Pathology, School of Medicine, Toho University,
Tokyo, Japan
|
|
Keloids are characterized by excessive deposition of collagen, which
might result from insufficient extracellular matrix degradation. Little
is known about the levels of matrix metalloproteinases (MMPs) and tissue
inhibitors of metalloproteinases (TIMPs) in keloids. We determined the
expression levels of MMPs and TIMPs in keloids and mature scars. Tissue
samples were collected from a total of 85 Japanese patients with keloids
(n=60) and mature scars (n=25). Immunohistochemical staining was
performed using the standard, indirect immunoperoxidase method to
investigate the expression levels of MMP-1, 2, and 9, and TIMP-1, 2, and
3 in keloids and mature scars. The expression levels of MMP-2, TIMP-2,
and -3 were significantly higher in keloids than mature scars, but no
significant differences in the expression levels of MMP-1, -9, and
TIMP-1 were detected. |
|
<< BACK |
PAGE TOP |
|
